Gage K. Moreno

Postdoctoral Fellow · Broad Institute of MIT and Harvard

Gage K. Moreno, Ph.D.

I lead research at the intersection of pathogen genomics, epidemiology, and computation to understand how respiratory viruses spread, evolve, and generate risk at population scale, informing surveillance, outbreak response, and pandemic preparedness.

About

I am a postdoctoral fellow in the Sabeti Lab at the Broad Institute of MIT and Harvard, where I lead research in genomic epidemiology of respiratory pathogens. My work integrates large-scale pathogen genomic surveillance with computational and epidemiologic methods to understand viral evolution and transmission in human populations.

I received my Ph.D. in Cellular and Molecular Pathology from the University of Wisconsin–Madison, where I characterized the introduction and early spread of SARS-CoV-2 in southern Wisconsin during the early COVID-19 pandemic.

Across my work, I aim to develop generalizable genomic surveillance approaches that translate sequencing data into actionable insight for outbreak response and pandemic preparedness. My research has been published in Cell, Nature Communications, NEJM, Nature Medicine, and other leading journals.

Research Interests

  • Genomic Epidemiology
  • Pathogen Surveillance
  • Viral Transmission
  • Metagenomics
  • Phylogenetics
  • Computational Biology

Education & Experience

2021 – Present

Postdoctoral Fellow

Broad Institute of MIT and Harvard

Advisor: Prof. Pardis Sabeti, Infectious Disease & Microbiome Program. Genomic epidemiology of respiratory pathogens using population-scale sequencing and computational methods.

2018 – 2021

Ph.D. in Cellular and Molecular Pathology

University of Wisconsin-Madison

Advisor: Prof. David O'Connor. Thesis: "Characterization of SARS-CoV-2 introduction and spread in southern Wisconsin."

2014 – 2018

B.S. in Genetics

University of Wisconsin-Madison

Certificate in Global Health.

Funding & Awards

2025 Rising Star Mentorship Program, Global Virus Network
2024 Early Career Investigator Award, Global Virus Network
2023 Precision & Genomic Medicine T32 Training Grant (NHGRI)
2022 Excellence and Achievement Award for COVID Genomic Surveillance, Broad Institute
2021 Best Plenary Talk, NLM Informatics Training Conference
2020 CIBM T15 Training Grant (NLM)

Selected Publications

* denotes co-first author · † denotes corresponding author

Nature Communications

Revealing fine-scale spatiotemporal heterogeneities in SARS-CoV-2 introduction and spread

Moreno GK*, Braun KM*, Riemersma KK*, Martin MA*, … O'Connor DH, Friedrich TC.

Nature Communications, 2020

Full Text →
PLoS Pathogens

Limited within-host diversity and tight transmission bottlenecks limit SARS-CoV-2 evolution

Braun K*, Moreno GK*, Wagner C*, … O'Connor DH, Bedford T, Friedrich TC, Moncla LH.

PLoS Pathogens, 2021

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Clinical Infectious Diseases

SARS-CoV-2 transmission in intercollegiate athletics not fully mitigated with daily antigen testing

Moreno GK*, Braun KM*, Pray IW*, … Friedrich TC, O'Connor DH.

Clinical Infectious Diseases, 2021

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Emerging Infectious Diseases

Interventions to Disrupt Coronavirus Disease Transmission at a University, Wisconsin, USA

Currie DW*, Moreno GK*, Delahoy MJ*, … Friedrich TC, Kirking HL, O'Connor DH, Killerby ME.

Emerging Infectious Diseases, 2021

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Clinical Infectious Diseases

Viral sequencing reveals healthcare personnel rarely become infected with SARS-CoV-2 through patient contact

Braun KM*, Moreno GK*, Accola MA*, … Friedrich TC, O'Connor DH.

Clinical Infectious Diseases, 2021

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PLoS Pathogens

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck

Braun KM*, Moreno GK*, Halfmann PJ*, … O'Connor DH, Friedrich TC.

PLoS Pathogens, 2021

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Journal of Virology

Long-Term Protection of Rhesus Macaques from Zika Virus Reinfection

Moreno GK*, Newman CM*, … Friedrich TC, O'Connor DH.

Journal of Virology, 2020

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Preprint

Limited SARS-CoV-2 diversity within hosts and following passage in cell culture

Moreno GK*, Braun KM*, Halfmann PJ*, Prall TM*, … Friedrich TC, O'Connor DH.

bioRxiv, 2020

Full Text →

Selected Talks

2025

Unraveling the Complexity of SARS-CoV-2 Transmission Across Scales

MassCPR Diagnostics, Surveillance, and Epidemiology · Boston, MA

2024

Viral Genomic Surveillance

Global Virus Network Short Course · Johns Hopkins University, Baltimore, MD

2023

Pathogen genomic surveillance informs on SARS-CoV-2 infection and transmission risk

UC Santa Cruz Next Wave of Faculty in Genomics Symposium · Santa Cruz, CA

2026

Population-scale pathogen genomic surveillance reveals age-specific drivers of SARS-CoV-2 transmission

NIAID GCID Annual Meeting · Boston, MA

2024

Insights from over 100,000 SARS-CoV-2 genomes with matched epidemiological data

Center for Genomic Medicine Seminar · Massachusetts General Hospital, Boston, MA

2023

Pathogen genomic surveillance sheds light on variant-specific infection and transmission risk

Wellcome Genome Campus · Hinxton, UK

Teaching & Mentoring

Bioinformatics: Metagenomics and Viral Phylogenetics

University of Sierra Leone, Bo, Sierra Leone · 2023

NGS for Pathogen Identification & Phylogenetic Trees

Université Cheikh Anta Diop, Dakar, Senegal · 2023

Mentoring

Mentored two undergraduates and one research assistant, leading to Ph.D. acceptances at Emory University and Medical College of Wisconsin, and an M.D. acceptance at UW-Madison.

In the Press

WIRED

When Covid Came for Provincetown

Cell

Cover article: Delta variant transmission from vaccinated individuals

The Boston Globe

Provincetown SARS-CoV-2 Delta outbreak investigation

Broad Institute

Several pre-existing RSV lineages powered the 2022 surge

New York Times

Background reporting on COVID-19 genomic surveillance

USA Today

Background reporting on SARS-CoV-2 transmission dynamics

Professional Service

Peer Review

Nature Communications, Nature Communications Biology, Clinical Infectious Diseases, Journal of Infectious Diseases, Virus Evolution, Public Health Reviews, Nature Scientific Reports

Grant Review

NIH CREID Pilot Research Program

Conference Review

One Health Genomics Symposium (2024), CREID Network Annual Meeting (2024)

Get in Touch

I'm always interested in collaborations and conversations about genomic epidemiology, pathogen surveillance, and computational biology.